Journal of Sports Science and Medicine
Journal of Sports Science and Medicine
 
FIND ARTICLES

jssm
jssm

Journal of Sports Science and Medicine
ISSN: 1303 - 2968
       SCImago 2016     SJR: 0.981   Cites per Doc. 2-Year: 2.04    3-Year: 2.17
JCReports 2016
    IF 2-Year: 1.797    3-Year: 1.970    5-Year: 2.061    Average Citations PI: 7.7
 
©Journal of Sports Science and Medicine (2008) 07, 365 - 370
Research article
Capsaicin Supplementation Fails to Modulate Autonomic and Cardiac Electrophysiologic Activity During Exercise in the Obese: with Variants of UCP2 and UCP3 Polymorphism
Ki Ok Shin1,2,, Toshio Moritani2

1 Pusan National University, Geumjeong-gu, Busan 609735, Korea
2 Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 6068501, Japan

Ki Ok Shin
✉ Research Institute of Sport Science, Pusan National University, Geumjeong-Gu, Busan 609735, Korea
Email: okshin21@pusan.ac.kr

Received:
08-04-2008 -- Accepted: 30-06-2008 --
Published (online): 01-09-2008

ABSTRACT

We investigated the effects of capsaicin supplementation (150mg) on alterations of autonomic nervous system (ANS) activity associated with adverse effects of cardiac depolarization-repolarization intervals during aerobic exercise in obese humans. Nine obese males (26.1 ± 1.5 yrs) volunteered between study designed. The cardiac ANS activities evaluated by means of heart rate variability of power spectral analysis and cardiac QT interval were continuously measured during 5-min rest and 30-min exercise at 50% of maximal ventilation threshold (50%VTmax) on stationary ergometer with placebo (CON) or capsaicin (CAP) oral administration chosen at random. The uncoupling protein (UCP) 2 and UCP 3 genetic variants of the subjects were analyzed by noninvasive genotyping method from collecting buccal mucosa cells. The results indicated that there were no significant differences in cardiac ANS activities during rest and exercise between CON and CAP trials. Although no significant difference, A/A allele of UCP2 polymorphism showed a reduced sympathetic nervous system (SNS) index activity compared to G/G + G/A allele during exercise intervention in our subjects. On the other hand, the data on cardiac QT interval showed no significant difference, indicating that oral administration of capsaicin did not cause any adverse effect on cardiac depolarization-repolarization. In conclusion, our results suggest that capsaicin supplementation 1 h before exercise intervention has no effect on cardiac ANS activities and cardiac electrical stability during exercise in obese individuals. Further studies should also consider genetic variants for exercise efficacy against obesity.

Key words: Heart rate variability power spectral analysis, cardiac depolarization-repolarization interval, uncoupling protein, capsaicin, exercise
Key Points
Obese individuals possess reduced cardiac autonomic nervous activities, especially sympathetic nervous activity associated with thermogenesis induced by capsaicin.
Lower sympathetic nervous activity may associate with -866 G/A variants of UCP2 polymorphism.
Capsaicin ingestion, however, may consider as a safe nutrient-aid with no adverse effects of cardiac electrical stability.

 


  

Article Tools
How to Cite
Citations in ScholarGoogle 
Statistics
Article views from September 2014
Abstract :1456
Full-text :1662
Pdf :22
Total :3140
New content alert
 
JSSM | Copyright 2001-2017 | All rights reserved. | LEGAL NOTICES | Publisher
It is forbidden the total or partial reproduction of this web site and the published materials, the treatment of its database, any kind
of transition and for any means, either electronic, mechanic or other methods, without the previous written permission of the JSSM.