Received: 08-04-2008 -- Accepted: 30-06-2008 --
Published (online): 01-09-2008
We investigated the effects of capsaicin supplementation (150mg) on alterations of autonomic nervous system (ANS) activity associated with adverse effects of cardiac depolarization-repolarization intervals during aerobic exercise in obese humans. Nine obese males (26.1 ± 1.5 yrs) volunteered between study designed. The cardiac ANS activities evaluated by means of heart rate variability of power spectral analysis and cardiac QT interval were continuously measured during 5-min rest and 30-min exercise at 50% of maximal ventilation threshold (50%VTmax) on stationary ergometer with placebo (CON) or capsaicin (CAP) oral administration chosen at random. The uncoupling protein (UCP) 2 and UCP 3 genetic variants of the subjects were analyzed by noninvasive genotyping method from collecting buccal mucosa cells. The results indicated that there were no significant differences in cardiac ANS activities during rest and exercise between CON and CAP trials. Although no significant difference, A/A allele of UCP2 polymorphism showed a reduced sympathetic nervous system (SNS) index activity compared to G/G + G/A allele during exercise intervention in our subjects. On the other hand, the data on cardiac QT interval showed no significant difference, indicating that oral administration of capsaicin did not cause any adverse effect on cardiac depolarization-repolarization. In conclusion, our results suggest that capsaicin supplementation 1 h before exercise intervention has no effect on cardiac ANS activities and cardiac electrical stability during exercise in obese individuals. Further studies should also consider genetic variants for exercise efficacy against obesity.
Ki Ok Shin, Toshio Moritani,
Capsaicin Supplementation Fails to Modulate Autonomic and Cardiac Electrophysiologic Activity During Exercise in the Obese: with Variants of UCP2 and UCP3 Polymorphism.
Journal of Sports Science and Medicine(07), 365 - 370.
| Copyright 2001-2017 | All rights reserved. | LEGAL
NOTICES | Publisher
It is forbidden the total or partial reproduction
of this web site and the published materials, the treatment of its database,
of transition and for any means, either electronic, mechanic or other
methods, without the previous written permission of the JSSM.