| This was a placebo-controlled, double-blind study designed to
evaluate the effect of a commercially available dietary supplement on upper-respiratory
tract symptoms (URTI) and mood state. Seventy-five marathon runners (35
men, 40 women) ranging in age from 18-53 years, mean age: 36 ± 9, self-administered
placebo, 250 mg or 500 mg of BETA 1,3/1,6 GLUCAN (commercial name Wellmune
WGP®) daily during the 4 week post-marathon trial period following the 2007
Carlsbad Marathon. Subjects filled out the profile of mood state (POMS)
assessment and a questionnaire style health log measuring health status
and URTI symptoms after 2- and 4-week treatment administrations. During
the course of the 4-week study, subjects in the treatment groups (250 mg
and 500 mg BETA-GLUCAN per day) reported significantly fewer URTI symptoms,
better overall health and decreased confusion, fatigue, tension, and anger,
and increased vigor based on the POMS survey compared to placebo. BETA-GLUCAN
may prevent URTI symptoms, and improve overall health and mood following
a competitive marathon.
Key
words: Dietary supplements, exercise, beta- Glucans, respiratory tract
infections.
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