Figure 3. During the 16 weeks experimental period, the last 8 weeks swimming exercise improves the deterioration of trabecular bone by high-fat diet. Representative micro-computed tomography image and microstructure analysis of trabecular bone in the femur (A and B) and tibia (C and D) after 8 weeks of swimming exercise. Data are presented as mean ± SE. * p < 0.05 vs. CD, † p < 0.05 vs. HFD by one-way ANOVA. CD, control diet; HFD, high-fat diet; HEx, high-fat diet and swimming exercise. BMD, bone mineral density; BV/TV, bone volume/total volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation.