Figure 4. Sex- and age-stratified associations between physical activity pattern and incident osteoarthritis. HRs and 95% CIs were estimated using Cox proportional hazards models separately among females, males, participants aged >=65 years, and participants aged <65 years. Models adjusted for age at accelerometer assessment, sex, ethnicity, education, Townsend deprivation index, smoking status, alcohol intake frequency, and BMI, with the stratification variable omitted from the corresponding model. Inactive participants accumulated <150 min/week of MVPA. Among participants accumulating >=150 min/week, WW participants accumulated >=50% of total weekly MVPA on the two most active days, whereas regularly active participants accumulated <50% on those days. The reference group was inactive within each stratum. Incident overall OA was defined as the first recorded ICD-10 M15-M19 diagnosis during follow-up among participants without OA at baseline. Squares indicate HR estimates and horizontal lines indicate 95% CIs. Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio; ICD-10, International Classification of Diseases, 10th Revision; MVPA, moderate-to-vigorous physical activity; OA, osteoarthritis; WW, weekend warrior.