Do Acute Exercise-Induced Activations of the Kynurenine Pathway Induce Regulatory T-Cells on the Long-Term? – A Theoretical Frame Work Supported by Pilot Data

Figure 2. Influence of exercise and inflammation on the kynurenine pathway. Thin colored arrows represent an acute effect and bold colored arrows represent a long-term effect. IDO: Indoleamine-2,3-Dioxygenase; IFN: interferon [IFN]-Î³; IL6: interleukin 6; TDO: Tryptophan-2,3-Dioxygenase; TNFα: Tumor necrosis factor α; T_cytotox: cytotoxic T cells; T_helper: T helper cells; T_reg: regulatory T-cells.