Gene | Polymorphism | Cohort (sex, sample size) | Population | Favorable allele/ genotype | Type of diet therapy | Outcome | References |
---|---|---|---|---|---|---|---|
rs4646994 I/D |
n=32, women 100% |
European | I | hypocaloric diet for 8 weeksTop of Form Bottom of Form | carriers of the I allele with significantly reduced relative body fat percentage compared to carriers of the DD genotype (-2.3±1.4% vs. -0.8±1.6%, P<0.05) | (Hamada
et al., |
|
rs2419621 C/T | n=44, women 100% |
European | Т | hypocaloric high-protein diet for 12 weeks | carriers of the T allele had significantly reduced body mass compared to carriers of the CC genotype (-9.3±1.8 kg vs. -7.4±2.1 kg, P=0.01), BMI (-3.4±0.5 units vs. -3.1±0.4 units, P=0.02), body fat mass (BFM) (-6.4±1.2 kg vs. -5.2±1.4 kg, P=0.01), and waist circumference (WC) (-8.6±0.8 cm vs. -6.1±1.1 cm, P=0.02) | (Jáuregui
et al., |
|
rs2419621 C/T | n=211, women 100% |
European (Canada) |
Т | hypocaloric diet for 24 weeks | carriers of the T allele had significantly reduced body fat mass (BFM) compared to carriers of the CC genotype (-3.82±1.66 kg, P<0.001), relative body fat mass (-2.99±1.08 kg, P<0.001), and visceral fat mass (-5.74±2.87 kg, P=0.003) | (Rajkumar
et al., |
|
rs10182181 A/G | n=147, women 67,3% |
European | G | hypocaloric low-fat diet for 16 weeks | carriers
of the G allele had significantly reduced trunk fat mass (n/d, P=0.04),
android fat mass (n/d, P=0.02), gynoid fat mass (n/d, P=0.03), and visceral fat mass (n/d, P=0.02) compared to carriers of the AA genotype. |
(Goni et
al., |
|
rs1042714 G/C | n=95 women 100% |
European | G | partial meal replacement hypocaloric diet 12 weeks | carriers
of the G allele had larger reductions: (CC versus CG + GG) body weight (-7.1±0.3 vs. -13.5±0.5 kg: P = 0.03), BMI (-0.9±0.1 vs -1.2±0.2 kg/m2; P = 0.03), fat mass (-4.9±0.5 vs. -10.2 ±1.2 kg; P = 0.01), and waist circumference (-5.1± 0.2 vs. -10.1±1.9 cm; P = 0.03) |
(de Luis
et al., |
|
rs4994 A/G |
n= 24, women 100% |
Mixed (USA) |
А | low-calorie diet for 13 months | carriers of the A allele had significantly reduced visceral fat mass by 43% compared to carriers of the GG genotype (-46±27 cm2 vs. -81±51 cm2, P=0.05) | (Tchernof
et al., |
|
rs6265 C/T |
n= 201, women n/d |
European | T | hypocaloric high-protein diet for 16 weeks | carriers of the T allele had significantly reduced body fat mass (BFM) compared to carriers of the CC genotype (-5.3±3.2 kg vs. -3.9±2.5 kg, P=0.023) | (Ramos-Lopez
et al., |
|
rs11030104 A/G | n= 201, women n/d |
European | G | hypocaloric high-protein diet for 16 weeks | carriers of the G allele significantly had reduced body fat mass (BFM) compared to carriers of the AA genotype (-5.2±3.1 kg vs. -3.8 ±2.4 kg, P=0.013) | (Ramos-Lopez
et al., |
|
rs10767664 T/A | n=80, women n/d |
European | АА | hypocaloric diet for 3 months | individuals with the AA genotype significantly reduced body mass (MT) (-3.4±2.9 kg vs. -1.7±2.0 kg, P=0.01), BMI more (-1.5±0.2 units vs. -1.2±0.5 units, P=0.02), body fat mass (BFM) more (-2.3±1.1 kg vs. -1.7±0.9 kg, P=0.009), and waist circumference (WC) more (-3.8±2.4 cm vs. -2.1±3.1 cm, P=0.008) compared to carriers of the G allele. | (de Luis
et al., |
|
rs3123554 A/G | n=280, women 76,6% |
European | GG | hypocaloric low-carbohydrate diet in conjunction with aerobic physical exercises for 12 weeks | carriers
of the GG genotype had significantly reduced body mass (BM) (-3.3±1.1
kg vs. -1.9±1.0 kg, P=0.01), BMI (-1.3±0.1 units vs. -1.0±0.5
units, P=0.03), body fat mass (BFM) (-2.7±1.1 kg vs. -2.2±0.7
kg, P=0.02), and waist circumference (WC) (-3.4±1.0 cm vs. -2.5±1.1 cm, P=0.009) compared to carriers of the A allele |
(de Luis
et al., |
|
rs3123554 A/G | n=280, women 76,6% |
European | GG | hypocaloric diet with aerobic physical exercises for 12 weeks | carriers
of the GG genotype had significantly reduced body mass (MT) (-4.0±1.2 kg vs. -2.1±1.1 kg, P=0.01), BMI (-1.3±0.2 units vs. -1.1±0.3 units, P=0.02), body fat mass (BFM) (-2.4±1.0 kg vs. -1.5±0.8 kg, P=0.02), and waist circumference (WC) (-3.7±1.1 cm vs. -2.9±1.0 cm, P=0.01), compared to carriers of the A allele |
(de Luis
et al., |
|
rs838147 A/G |
n=715, women 61% |
Mixed (USA) | G | hypocaloric low-fat diet for 2 years | carriers of the G allele had significantly reduced body fat mass (BFM) (n/d, P=0.01) and trunk fat mass (n/d, P=0.02) compared to carriers of the AA genotype | (Heianza
et al., |
|
rs9939609 T/A | n=233, women 75,9% |
European | А | hypocaloric diet with high polyunsaturated fat content in conjunction with aerobic physical exercises for 12 weeks | carriers of the A allele had significantly reduced body mass (MT) (-5.1±3.9 kg vs. -3.0±2.8 kg, P<0.05), BMI (-2.0±1.4 units vs. -1.1±1.2 units, P<0.05), and body fat mass (BFM) (-4.2±2.9 kg vs. -3.0±2.8 kg, P<0.05) compared to carriers of the TT genotype | (de Luis
|
|
rs9939609
T/A |
n=195, women 70,2% |
European | TT | hypocaloric high-protein diet for 9 months | carriers of the TT genotype had significantly reduced body mass (MT) (n/d, P<0.05), BMI (n/d, P<0.05), and body fat mass (BFM) (n/d, P<0.05) compared to carriers of the A allele | (de Luis
|
|
rs9939609
T/A |
n=195, women 70,2% |
European | TT | hypocaloric diet for 9 months | carriers of the TT genotype with significantly reduced body mass (MT) (n/d, P<0.05), BMI (n/d, P<0.05), and body fat mass (BFM) (n/d, P<0.05) compared to carriers of the A allele | (de Luis
|
|
rs1558902 T/A | n=742, women 61% |
Mixed | А | high-protein diet for 2 years | carriers of allele A, compared to carriers of the TT genotype, significantly reduced total body fat (n/d, P=0.049), visceral fat (n/d, P=0.012), and subcutaneous fat (n/d, P=0.002) | (Zhang
et al., |
|
rs4988235 G/A | n=583, women 56,3% |
European (USA) | G | high-protein diet for 2 years | carriers of the G allele, compared to carriers of the AA genotype, had significantly reduced relative body fat (n/d, P=0.04), subcutaneous fat (n/d, P=0.04), visceral fat (n/d, P=0.03), and total body fat (n/d, P=0.03) | (Heianza
et al., |
|
rs1137100 A/G | n=170, women 47,1% |
European | АА | hypocaloric diet for 8 weeks | carriers of the AA genotype, compared to carriers of the G allele, had significantly reduced body fat (-4.1±2.1% vs. -2.9±3.6%, P=0.013) | (Abete
et al., |
|
rs2605100 A/G | n= 201, women n/d |
European | GG | hypocaloric high-protein diet for 16 weeks | carriers of the GG genotype, compared to carriers of the A allele, significantly reduced waist circumference (WC) (-9.8±3.9 cm vs. -8.0±4.9 cm, P=0.046) and body fat mass (BFM) (-4.9±2.7 kg vs. -3.8±2.8 kg, P=0.05) | (Ramos-Lopez
et al., |
|
rs1801133 С/Т | n= 56, women 66,1% |
European | СC | hypocaloric Mediterranean diet for 12 weeks | carriers of the CC genotype, compared to carriers of the T allele, had significantly reduced relative body mass (-9.3±4.0% vs. -8.6±3.5%, P<0.05) and relative body fat mass (BFM) (-18.0±8.6% vs.-13.1±7.8%, P<0.05) | (Renzo
et al., |
|
rs10830963 C/G | n=80, women 75,0% |
European | СС | hypocaloric Mediterranean diet for 12 weeks | male carriers of the CC genotype, compared to carriers of the G allele, had significantly reduced body mass (-3.8±3.1 kg vs. -3.1±3.2 kg, P<0.05), BMI (-0.9±1.0 units vs. -0.7±1.0 units, P<0.05), and body fat mass (BFM) (-2.4±1.5 kg vs. -1.1±1.1 kg, P<0.05) among women, carriers of the CC genotype, compared to carriers of the G allele, had significantly reduced body mass (-3.2±1.1 kg vs. -2.1±1.0 kg, P<0.05), BMI (-1.1±1.0 units vs. -0.6±1.3 units, P<0.05), and body fat mass (BFM) (-2.4±1.0 kg vs. -1.3±1.2 kg, P<0.05) | (de Luis
et al., |
|
rs10830963 C/G | n=361, women n/d |
European | СС | hypocaloric diet with a high content of monounsaturated fats or with a high content of polyunsaturated fats for 12 weeks | carriers of the CC genotype, compared to carriers of the G allele, significantly reduced body mass (-4.1±0.9 kg vs. -2.9±0.8 kg, P<0.05), BMI (-0.7±1.1 units vs. -0.5±1.2 units, P<0.05), body fat (-3.0±0.8 kg vs. -2.0±1.0 kg, P<0.05), and waist circumference (-3.4±1.0 cm vs. -2.9±0.9 cm, P<0.05) on a hypocaloric diet with a high content of monounsaturated fats carriers of the CC genotype, compared to carriers of the G allele, significantly reduced body mass (-3.7±1.0 kg vs. -2.5±0.9 kg, P<0.05), BMI (-0.7±1.0 units vs. -0.2±1.1 units, P<0.05), body fat more (-3.3±1.0 kg vs. -1.4±0.9 kg, P<0.05) and waist circumference (-3.8±1.0 cm vs. -2.6±0.8 cm, P<0.05) on a hypocaloric diet with a high content of polyunsaturated fats | (de Luis
et al., |
|
rs10830963 С/G | n=270, women % |
European | СС | highly hypocaloric high-protein/low- carbohydrate diet for 9 months. | carriers of the CC genotype, compared to carriers of the G allele, had significantly reduced BMI (-3.3±0.2 units vs. -3.2±0.2 units, P=0.02), body mass (-8.6±1.1 kg vs. -6.2±0.9 kg, P=0.01), body fat mass (BFM) (-6.2±1.8 kg vs. -3.7±1.2 kg, P=0.01), and waist circumference (WC) (-11.7±2.1 cm vs. -6.7±1.9 cm, P=0.02) | (de Luis
et al., |
|
rs10830963 С/G | n=270, women % |
European | СС | highly hypocaloric diet for 9 months | carriers of the CC genotype, compared to carriers of the G allele, significantly reduced BMI (-3.1±0.2 units vs. -2.7±0.3 units, P=0.04), body mass (-7.6±1.4 kg vs. -5.1±1.2 kg, P=0.03), body fat mass (BFM) (-6.3±1.2 kg vs. -4.2±1.1 kg, P=0.03), and waist circumference (WC) (-10.7±1.4 cm vs. -6.3±1.8 cm, P=0.01) | (de Luis
et al., |
|
NFATC2IP | rs11150675 G/A | n=692, women 61,1% |
Mixed | A | low-carbohydrate diet for 2 years | carriers of the A allele, compared to carriers of the G allele, significantly reduced body fat mass (BFM) (-5.2±1.1 kg vs. -4.2±1.0 kg, P=0.02) and trunk fat (-16.1±3.2% vs. -12.8±2.8%, P=0.01) | (Sun et
al., |
rs16147 T/C | n=723, women 61% |
Mixed | C | low-carbohydrate diet for 2 years | carriers of the C allele, compared to carriers of the T allele, had significantly reduced waist circumference (WC) (n/d, P<0.001) after 6 months, subcutaneous fat (n/d, P=0.04), body fat mass (BFM) (n/d, P=0.05), and abdominal fat (n/d, P=0.01) after 2 years | (Lin et
al., |
|
rs1053049 C/T | n=156, women 60,1% |
European | Т | low-fat diet with aerobic exercise for 9 months | carriers
of the TT genotype, compared to carriers of the C allele, had significantly
reduced non-visceral fat mass (-1.6 kg vs. -0.8 kg, P=0.02) and visceral
fat (-0.4 kg vs. -0.3 kg, P=0.01) |
(Thamer
et al., |
|
rs2267668 G/A | n=156, women 60,1% |
European | АА | low-fat diet with aerobic exercise for 9 months | carriers of the AA genotype, compared to carriers of the G allele, had significantly reduced non-visceral fat (-1.4 kg vs. -0.6 kg, P=0.04) | (Thamer
et al., |
|
rs1801282 C/G | n=144, women100% |
European | G | hypocaloric Mediterranean diet for 16 weeks | carriers of the G allele, compared to carriers of the CC genotype, had significantly reduced abdominal fat (-4.23±0.41 kg vs. -3.31±0.26 kg, P<0.05) | (Chmurzynska
et al., |
|
rs7903146 C/T | n= 771, women n/d |
European | T | highly hypocaloric low-fat diet over 10 weeks | individuals with the TT genotype on a low-fat diet lost significantly more body mass (-6.9±4.0 kg vs. -4.8±3.3 kg, P=0.023), fat mass (-5.4±3.4 kg vs. -4.4±3.2 kg, P=0.048), and waist circumference (WC) (-6.8±6.1 cm vs. -4.2±4.8 cm, P=0.023) compared to those on a low-carbohydrate diet; carriers of the C allele were equally effective in reducing body mass regardless of the diet type | (Grau et
al., |
|
rs7903146 C/T | n= 201, women n/d |
European | TT | hypocaloric high-protein diet for 16 weeks | individuals
with the TT genotype, compared to carriers of the C allele, had significantly reduced body fat mass (BFM) (-5.6±2.4 kg vs. -4.1±2.8 kg, P=0.049) |
(Ramos-Lopez
et al., |
|
rs660339 G/A |
n= 386, women 100% |
East Asian | G | Caloric restriction diet for 4 weeks. | carriers of the G allele had significantly reduced body fat mass (BFM) (-5.0±0.2 kg vs. -3.9±0.3 kg, P=0.016) compared to carriers of the AA genotype | (Cha et
al., |
|
rs659366 G/A |
n= 458, women 100% |
East Asian | G | markedly hypocaloric diet for 4 weeks. | individuals with the G allele showed a significant reduction in BMI (-2.8±0.8 units vs. -2.4±1.0 units, P=0.02) and body fat mass (BFM) (-5.3±3.6 kg vs. -4.2±2.1 kg, P=0.03) compared to those with the AA genotype | (Yoon et
al., |
|
rs1800849 rs2075576 rs1800006 rs1685325 rs2734827 rs2075577 |
n= 214, women 100% the average age is 28.6±9.6 years |
East Asian | Haplotype [CGTACC] | extremely hypocaloric diet for 4 weeks | carriers of the haplotype [CGTACC], compared to carriers of the haplotype [TCCGTT], had significantly reduced body mass (BMI: -7.7±2.2 kg vs. -6.5±2.5 kg, P=0.016), body mass index (BMI: -2.98±0.91 vs. -2.54±0.94, P=0.039), and fat mass (FM: -5.5±4.6 kg vs. -4.3±1.8 kg, P=0.028) | (Cha et
al., |