Table 2. Cardiorespiratory responses to submaximal cycle ergometry before (pre-test) and after (re-test) 3 weeks of intake of L-arginine-L-aspartate or placebo. Data represent means (±SD).
PLACEBO (n=8) L-ARGININE-L-ASPARTATE (n=8)
Rest 50 watts 100 watts 150 watts Rest 50 watts 100 watts 150 watts
Heart Rate
(bpm)		 Pre-Test
Re-Test		 80 (12)
82 (18)		 100 (9)
104 (9)		 117 (10)
121 (10)		 134 (10)
138 (10)		 77 (13)
80 (15)		 99 (8)
94 (6) *		 114 (8)
111 (8) *		 134 (8)
129 (7) **
Systolic
BP (mm Hg)		 Pre-Test
Re-Test		 128.8 (22.1)
118.6 (13.6)		 142.4 (16.5)
131.3 (14.5)		 151.8 (17.8)
147.4 (20.7)		 170.4 (20.2)
165.1 (14.4)		 133.8 (16.2)
122.4 (12.8)		 154.0 (13.9)
139.0 (14.4)		 161.6 (20.5)
148.6 (17.8)		 178.9 (22.5)
173.5 (17.2)
Diastolic
BP (mm Hg)		 Pre-Test
Re-Test		 76.0 (8.6)
76.1 (12.7)		 70.0 (11.9)
68.4 (14.1)		 69.4 (14.2)
69.4 (13.2)		 70.3 (9.4)
66.7 (12.6)		 77.4 (18.2)
76.3 (10.1)		 72.3 (18.9)
71.3 (9.0)		 70.5 (13.2)
70.4 (12.3)		 70.0 (16.4)
71.6 (9.0)
RPP Pre-Test
Re-Test		 10344 (2578)
9869 (2725)		 14123 (1689)
13720 (2122)		 17701 (2610)
17696 (2315)		 22848 (2973)
22719 (2313)		 10285 (1950)
9740 (1667)		 15163 (1401)
13057 (1556)		 18350 (2626)
16426 (2315)		 23908 (3646)
22533 (2847)
VE (l·min-1) Pre-Test
Re-Test		 15.5 (4.6)
14.6 (4.3)		 27.7 (5.5)
28.4 (4.3)		 38.5 (4.2)
39.6 (4.5)		 53.2 (6.4)
54.9 (5.5)		 14.9 (3.2)
15.6 (2.2)		 31.7 (4.8)
28.5 (3.6)		 39.4 (3.9)
37.6 (3.1) *		 53.3 (5.2)
50.7 (4.5) *
VO2 (l·min-1) Pre-Test
Re-Test		 .410 (.072)
.375 (.090)		 1.082 (.118)
1.065 (.131)		 1.577 (.127)
1.551 (.123)		 2.105 (.188)
2.089 (.149)		 .429 (.094)
.418 (.067)		 1.183 (.191)
1.100 (.136)		 1.651 (.105)
1.551 (.116)		 2.214 (.160)
2.071 (.139)
VCO2 (l·min-1) Pre-Test
Re-Test		 .380 (.090)
.347 (.086)		 .952 (.134)
.955 (.159)		 1.459 (.104)
1.482 (.134)		 2.105 (.161)
2.163 (.143)		 .397 (.102)
.382 (.052)		 1.087 (.153)
.926 (.097) *		 1.508 (.111)
1.403 (.132)		 2.199 (.140)
2.032 (.134)**
VE / VO2 Pre-Test
Re-Test		 37.2 (5.8)
38.9 (4.5)		 25.6 (3.5)
26.7 (2.3)		 24.5 (2.5)
25.7 (3.5)		 25.3 (2.5)
26.4 (3.5)		 35.2 (6.2)
38.7 (11.3)		 27.1 (4.2)
26.3 (4.7)		 24.0 (3.2)
24.4 (2.8)		 24.2 (2.6)
24.6 (3.3)
VE / VCO2 Pre-Test
Re-Test		 40.5 (4.6)
42.0 (4.0)		 29.1 (3.5)
29.9 (2.4)		 26.4 (2.6)
26.8 (2.3)		 25.3 (2.0)
25.4 (2.1)		 38.2 (6.1)
41.4 (7.3)		 29.3 (3.6)
31.1 (5.2)		 26.3 (3.6)
27.0 (3.0)		 24.3 (2.5)
25.1 (3.1)
RER Pre-Test
Re-Test		 .92 (.10)
.93 (.11)		 .88 (.04)
.89 (.04)		 .93 (.04)
.96 (.06)		 1.00 (.05)
1.04 (.07)		 .92 (.10)
.93 (.16)		 .92 (.07)
.85 (.08)		 .91 (.05)
.90 (.05)		 .99 (.04)
.98 (.05) *
** p < 0.01 for changes between groups. Abbreviations: BP = Blood pressure, VE = Minute ventilation, RPP = Rate pressure product, RER = Respiratory exchange ratio.* p < 0.05;