Table 2 List of the 25 genetic markers found to be significant different between the SF and the C groups, hence associated with SF pathogenesis: both SNPs and haplotypes analyses within the following 9 genes: .
| Gen |
Genetic marker |
† Data |
OR (95% CI, p-value) |
#Model analysis |
| NR3C1 |
SNP |
rs4244032 |
G/A (A/A) |
.94(.39-.61, p=.04) |
CD |
| G/A (A/A-G/G) |
.58(.38-.89, p=.01) |
OD |
| rs 12656106 |
G/C (G/G) |
.57(.36-.91, p=.04) |
CD |
| C/C (G/G) |
.54(.29-.98, p=.04) |
CD |
| G/C-C/C (G/G) |
.56(.36-.87, p=.01) |
D |
| Hap. |
GAAAA |
13.74(6.66) |
2.11 (1.01-4.39, p=.05) |
CD |
| GT |
44.12(36.87) |
1.49 (1.07-2.07, p=.02) |
CD |
| ANKH |
SNP |
rs4701616 |
C/T/-C/C (C/T) |
1.67(l.ll-2.53,p = .01) |
D |
| VDR |
SNP |
rs4328262 |
G/T(T/T) |
.57(.33-.99,p=.04) |
D |
| G/T (T/T-G/G) |
.53(.32-.88,p=.01) |
OD |
| Hap. |
ACCTATAAG |
2.65 (3.3) |
.16(.04-.62,p=.01) |
CD (1st block) |
| CCAGGCAC |
4.2 (NA) |
12.22(1.45-102.7, p=.02) |
CD (2nd block) |
| R0R2 |
SNP |
rsl0992075 |
G/A (A/A) |
1.68(1.04-2.69, p = .02) J |
CD |
| Hap. |
CCCTACC |
6.97(4.45) |
2.71 (1.03-7.12, p = .04) |
CD (block 5a) |
| CALCR |
SNP |
rsl2154667 |
T/T (C/C) |
.48(.27-.85, p=.01) |
CD |
| C/T (C/C) |
.47(.29-.77, p=.01) |
CD |
| C/T-T/T (C/C) |
.47(.30-.75, p=.001) |
D |
| rsl 548456 |
T/T (C/C) |
2.23 (1.2-4.15, p=.01) |
CD |
| T/T (C/C-C/T) |
2.39(1.35-4.25, p=. 002) |
R |
| Hap. |
CGTTCTCCGA |
12.91 (8.43) |
1.93 (1.09-3.43, p=.003) |
CD |
| CC |
16.05(13.75) |
1.68 (1.05-2.71, p = .02) J |
CD |
| CT |
41.25(33.96) |
1.47(1.08-2.02, p = .02) |
CD |
| IL6 |
SNP |
rsl554606 |
T/T (G/G-G/T) |
3.48(1.35-8.94, p=.005) |
R |
| C0L1A2 |
SNP |
rs420257 |
C/C (T/T-T/C) |
2.29 (1.10-4.80, p = .02) ‡ |
R |
| rs42517 |
G/G (A/A-A/G) |
11.03(1.36-89.20, p=.003) ‡ |
R |
| rs42522 |
G/G (A/A-A/G) |
2.21 (1.02-4.77, p = .04) ‡ |
R |
| rs24531 |
A/G (G/G) |
.54(.34-.88,p=.01)‡ |
CD |
| rs413826 |
C/G-G/G (C/C) |
.53(.32-.88,p=.01)‡ |
D |
| CBG |
SNP |
rsl 1629171 |
C/T-T/T (C/C) |
1.65(1.09-2.50, p = .02) |
D |
| rs2281518 |
T/C (T/T-C/C) |
1.52(1.00-2.32, p = .05) |
OD |
| Hap. |
CATCCT |
14.5(9.75) |
1.82 (1.03-3.22, p = .04) |
CD |
| LRP4 |
SNP |
rs2306033 |
.4/G-A//4 (G/G) |
.39 (.21-0.72, p =.002) |
D |
Inducer marker / Protective marker (Italic style).‡ Adjusted for BMI† SNP analysis- SNPs genotyping using the relevant model: CD- Co dominant model, whereas rare genotype (in comparison to the frequent genotype), e.g., A/T (T/T) = the frequent genotype is T/T; D- Dominant model, whereas both heterozygous and rare homozygous (in comparison to the frequent genotype, the frequent homozygous)side; OD- Over dominant model, whereas heterozygous genotype (in comparison to both homozygous genotypes), e.g., A/C (A/A-C/C); R- Recessive model, whereas rare homozygous (in comparison to both: frequent homozygous and heterozygous genotypes). - Distribution (%) among SF group (in brackets the haplotype frequency among the C group); e.g., 2.65 (3.3) = 2.65% distribution among the SF group in comparison to 3.3% distribution among the C group# Model analysis: CD=Co dominant SNP analysis; D=Dominant SNP analysis; OD=Over dominant SNP analysis.
