 |
| |
| Gene | Polymorphism | Cohort (sex, sample size) | Population | Favorable allele/ genotype | Type of exercise | Outcome | References |
|---|---|---|---|---|---|---|---|
| rs116143768 C/T | n=126, women 100% |
European | Т | aerobic training for 12 weeks | carriers of the T allele, compared to those with the CC genotype, had significantly reduced relative fat mass (by 31.4% vs. -3.8%, P=1.18×10-9) | (Bojarczuk
et al., |
|
| rs28365031
I/D rs4994 A/G rs1042714 G/C |
n=70, women 78,6% |
Mixed (USA) |
Haplotype
[ Haplotype [ |
aerobic exercises of moderate intensity for 24 weeks | carriers
of the haplotype [ |
(Phares
et al., |
|
| rs1042713
G/A rs1042714 G/C rs4994 A/G rs553668 G/A |
n=163, women 100% |
European | Alleles rs1042713 A, rs1042714 C, rs553668 A in combination | aerobic training for 12 weeks | carriers of a small number (0–3) of obesity risk alleles [rs1042713 G, rs1042714 G, rs553668 G] had significantly reduced relative total body fat compared to carriers of a high number (5-6) of risk alleles (7.7±9.8% vs. 4.0±9.4%, P = 0.0362) | (Leońska-Duniec
et al., |
|
| rs1042714 G/C | n=70, women 78,6% |
Mixed (USA) |
G | aerobic exercises of moderate intensity for 24 weeks | carriers of the G allele, compared to carriers of the C allele, had significantly reduced relative total body fat (-2.7±0.4% vs. -1.3±0.4%, P=0.015) and relative trunk fat (-3.2±0.5% vs. -1.5±0.5%, P=0.02 | (Phares
et al., |
|
| rs4994 A/G | n=70, women 78,6% |
Mixed (USA) |
G | aerobic exercises of moderate intensity for 6 months | carriers of the G allele, compared to individuals with the AA genotype, had significantly reduced relative total body fat (-2.7±0.5% vs. -1.3±0.3%, P=0.027) and relative trunk fat (3.1±0.6% vs. -1.6±0.3%, P=0.03) | (Phares
et al., |
|
| rs4994 A/G | n=65, women 72,3% |
European | AA | aerobic exercise on the background of a hypocaloric diet for 12 weeks | individuals with the AA genotype, compared to individuals with the AG genotype, had significantly reduced BMI (n/d, P<0.05), body mass (n/d, P<0.05), fat mass (n/d, P<0.05), and waist circumference (WC) (n/d, P<0.05). | (de Luis
et al., |
|
| rs4917 T/C | n=105, women 100% |
European | TT | high-intensity aerobic exercise on the background of a hypocaloric diet for 10 weeks | carriers of the TT genotype, compared to carriers of the C allele, had significantly reduced trunk fat (-3.7±11.4 kg vs. 1.5±15.1 kg, P<0.005) | (Suchanek
et al., |
|
| rs4680 G/A | n=173, women 100% | Mixed (USA) |
GG | aerobic exercise of moderate intensity for 1 year | carriers of the GG genotype, compared to carriers of the AA genotype, had significantly reduced relative total body fat (-1.9% vs. -0.7%, P=0.05) | (Tworoger
et al., |
|
| (TTTA)n | n=173, women 100% | Mixed (USA) |
(TTTA)2-11 | aerobic exercise of moderate intensity for 1 year | carriers of the (TTTA)2-11 allele, compared to non-carriers, had significantly reduced total body fat (-3.1 kg vs. -0.5 kg, P = 0.01) and relative total body fat (-2.4% vs. -0.6%, P=0.001) | (Tworoger
et al., |
|
| rs1800497 C/T | n=127, women 100% |
European | С | resistance training with weights on the background of a hypocaloric diet for 6 months | carriers of the C allele, compared to carriers of the T allele, had significantly reduced BMI (-2.3 units vs. -1.4 units, P=0.001), body mass (-7 kg vs. -4.4 kg, P=0.001), and body fat mass (-6.2 kg vs. -4.4 kg, P=0.001) | (Cameron
et al., |
|
| rs1799883 T/C | n= 69, women 79,7%, |
European | С | aerobic exercise in conjunction with a hypocaloric diet for 12 weeks | carriers of the C allele, compared to individuals with the TT genotype, had significantly reduced total body fat (-1.6 kg vs.-1.3 kg, P<0.05) | (de Luis
et al., |
|
| rs8050136 C/A | n= 481, women 51,8% |
European | СС | aerobic exercise of low/moderate intensity for 20 weeks | carriers of the CC genotype, compared to individuals with the AA genotype, had significantly reduced total body fat (-0.8±0.1 kg vs. -0.2±0.2 kg, P=0.0065) and relative total body fat (-1.0±0.1% vs. -0.3±0.2%, P=0.0087) | (Rankinen
et al., |
|
| rs1057972 A/T | n= 163, women 100% |
European | A | aerobic exercise of moderate intensity for 12 weeks | carriers of the A allele, compared to individuals with the TT genotype, had significantly reduced relative total body fat (n/d, P=0.00002) | (Ficek
et al., |
|
| rs1589241
T/C rs1057972 A/T |
n= 163, women 100% |
European | Haplotype [TA] | aerobic exercise of moderate intensity for 12 weeks | carriers of the [TA] haplotype, compared to carriers of the [AT] haplotype, had significantly reduced relative visceral fat (n/d, P=0.027) | (Ficek
et al., |
|
| rs7566605 C/G | n=752, women 60% |
European | GG | resistance training with added weight for 12 weeks | among men, carriers of the GG genotype, compared to carriers of the C allele, had significantly reduced relative subcutaneous fat (-1.0±1.7% vs.6.4±1.8%, P=0.035) | (Orkunoglu-Suer
et al., |
|
| rs6971091 G/A | n=139, women 100% |
European | GG | high-intensity aerobic exercise in conjunction with a hypocaloric diet for 10 weeks | carriers of the GG genotype, compared to carriers of the A allele, significantly reduced fat mass (-5.0±3.3 kg vs. -3.7±3.5 kg, P=0.037) | (Suchánek
et al., |
|
| rs1052700 A/T | n=30, women 100% |
American | TT | high-Intensity Interval Training (HIIT) alongside a hypocaloric diet for 12 weeks | carriers of the TT genotype, compared to carriers of the AA and AT genotypes, had significantly reduced body fat mass (BFM)(-5.1±1.8 kg vs. -1.8±1.4 kg and vs. -2.1±2.3 kg, respectively, P=0.04) | (Andrade-Mayorga
et al., |
|
| rs1801282 C/G | n=201, women 100% |
European | СС | aerobic training for 12 weeks | carriers
of the CC genotype had significantly reduced fat mass (not specified, P=0.0002) and relative fat mass (not specified, P=0.00003) compared to carriers of the G allele |
(Zarebska
et al., |
|
| rs1801282 C/G | n=79, women 45,6% |
European | G | aerobic exercises for 10 weeks | carriers of the G allele, compared to individuals with the CC genotype, had significantly reduced body mass (-1.8±1.8 kg vs. -0.3±1.4 kg, P<0.05 | (Østergård
et al., |
|
| rs1801282 C/G | n = 1004, women n/d |
Mixed | G | moderate-intensity physical activity for one year (e.g., walking) | carriers of the G allele, compared to individuals with the CC genotype, significantly reduced body mass (n/d, P = 0.04) and subcutaneous fat mass (n/d, P=0.03) | (Franks
et al., |
|
| rs17650401 С/Т | n=39, women 100% |
European | T | high-intensity aerobic exercise alongside a hypocaloric diet for 12 weeks | carriers
of the T allele, compared to individuals with the CC genotype, had significantly
reduced relative body fat mass (BFM) by 2.5 times (P = 0.00013) |
(Mazur
et al., |
|
| rs7903146 C/T | n=309, women 62,8% |
European | СС | moderate-intensity physical activity over the course of 2 years | carriers
of the CC genotype, compared to carriers of the T allele, significantly
reduced BMI (-1.2±1.6 units vs. -0.7±1.5 units, P=0.0034),
non-visceral fat mass (-2.7±3.6 kg vs. -1.3±2.9 kg, P=0.0022), and visceral fat mass (-0.5±0.6 kg vs. -0.3±0.6 kg, P=0.0165) |
(Haupt
et al., |
|
| I/D | n=42, women 100% |
East Asian | D | moderate-intensity aerobic exercise for 6 months | carriers of the DD and ID genotypes, compared to carriers of the II genotype, had significantly reduced body mass (-1.57 kg, P=0.001 for DD; -2.03 kg, P=0.003 for ID), body mass index (BMI) (-0.64 units, P=0.001 for DD; -0.83 units, P=0.003 for ID), relative fat mass (-1.24%, P=0.014 for DD), and waist circumference (WC) (-5.56 cm, P<0.001 for DD; -5.63 cm, P<0.001 for ID) | (Lim and
Shin, |
|
| rs1800849 C/T | n=107, women 74,7% |
European | СС | low-intensity aerobic exercise alongside a hypocaloric diet for 12 weeks | carriers of the CC genotype, compared to carriers of the T allele, had significantly reduced fat mass (-2.9 kg, P<0.05) and waist circumference (WC) (-3.5 cm, P<0.05) | (de Luis
et al., |