Table 2. Summary of quality assessment findings (GRADE).

Outcome	Certainty assessment							™– of patients			Effect	Certainty
	™– of studies	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	CART	ST	p-value	Absolute (95% CI)
BW (kg)	5	RCT	not serious	not serious	not serious	seriousb	none	231	224	0.95	SMD 0.04 lower (1.23 lower to 1.15 higher)	⊕⊕⊕◯ Moderate
BMI (kg/m2)	6	RCT	seriouse	seriousc	not serious	seriousb	none	213	216	0.04	SMD 0.57 lower (1.12 lower to 0.02 lower)	⊕◯◯◯ Very low
BMI (≤16 wks)	4	RCT	seriouse	not serious	not serious	seriousb	none	179	189	0.04	SMD 0.21 lower (0.42 lower to 0)	⊕⊕◯◯ Low
BMI (>16 wks)	2	RCT	seriouse	very seriousa	not serious	seriousb	none	34	27	0.27	SMD 2.49 lower (6.91 lower to 1.93 higher)	⊕◯◯◯ Very low
HC (cm)	2	RCT	seriousd	not serious	not serious	seriousb	none	97	94	0.02	MD 3.14 lower (4.77 lower to 1.52 lower)	⊕⊕◯◯ Low
WC (cm)	2	RCT	seriousd	not serious	not serious	seriousb	none	97	94	0.19	MD 3.63 lower (9.02 lower to 1.77 higher)	⊕⊕◯◯ Low
WHR	2	RCT	seriousd	seriousc	not serious	seriousb	none	60	62	0.34	MD 0.05 lower (0.15 lower to 0.05 higher)	⊕◯◯◯ Very low
BF (%)	6	RCT	seriousd	seriousc	not serious	seriousb	none	157	148	0.02	SMD 0.5 lower (0.93 lower to 0.07 lower)	⊕◯◯◯ Very low
FM (kg)	4	RCT	not serious	seriousc	not serious	seriousb	none	174	173	0.04	SMD 0.76 lower (1.44 lower to 0.08 lower)	⊕⊕◯◯ Low
FFM (kg)	2	RCT	seriousd	not serious	not serious	seriousb	none	56	55	<0.01	SMD 1.03 higher (0.63 higher to 1.43 higher)	⊕⊕◯◯ Low
TC (mmol/L)	2	RCT	not serious	not serious	not serious	seriousb	none	87	83	<0.01	SMD 0.95 lower (1.37 lower to 0.52 lower)	⊕⊕⊕◯ Moderate
HDL-C (mmol/L)	3	RCT	not serious	very seriousa	not serious	seriousb	none	133	128	0.008	MD 8 higher (2.05 higher to 13.94 higher)	⊕◯◯◯ Very low
LDL-C (mmol/L)	2	RCT	not serious	very seriousa	not serious	seriousb	none	56	55	<0.01	SMD 1.4 lower (5.22 lower to 2.41 higher)	⊕◯◯◯ Very low
TG (mg/Dl)	1	RCT	not seriousa	very seriousa	not serious	seriousb	none	46	45	<0.01	MD 81.9 lower (91.21 lower to 72.59 lower)	⊕◯◯◯ Very low
IL-6 (pg/mL)	6	RCT	not serious	not serious	not serious	seriousb	none	177	163	0.33	SMD 0.11 lower (0.32 lower to 0.11 higher)	⊕⊕⊕◯ Moderate
IL-8 (pg/mL)	3	RCT	not serious	very seriousa	not serious	seriousb	none	86	85	0.20	SMD 1.32 lower (3.33 lower to 0.7 higher)	⊕◯◯◯ Very low
TNF-α (pg/mL)	4	RCT	not serious	seriousc	not serious	seriousb	none	130	126	0.03	SMD 0.89 lower (1.7 lower to 0.08 lower)	⊕⊕◯◯ Low
CRP (mg/dL)	3	RCT	not serious	very seriousa	not serious	seriousb	none	113	105	0.23	SMD 1.69 lower (4.42 lower to 1.05 higher)	⊕◯◯◯ Very low
ADPN (ug/mL)	2	RCT	seriousd	very seriousa	not serious	seriousb	none	61	59	0.36	MD 5.06 higher (5.82 lower to 15.93 higher)	⊕◯◯◯ Very low
LEP (ng/mL)	4	RCT	not serious	seriousc	not serious	seriousb	none	122	114	0.03	SMD 0.63 lower (1.2 lower to 0.06 lower)	⊕⊕◯◯ Low
NK cells (%)	2	RCT	not serious	not serious	not serious	seriousb	none	50	47	0.04	SMD 0.42 higher (0.01 higher to 0.82 higher)	⊕⊕⊕◯ Moderate
FA (score)	4	RCT	seriouse	very seriousa	not serious	seriousb	none	168	180	0.03	SMD 0.98 lower (1.85 lower to 0.11 lower)	⊕◯◯◯ Very low
SQ (score)	2	RCT	not serious	seriousf	not serious	seriousb	none	70	72	0.01	SMD 1.17 lower (1.76 lower to 0.57 lower)	⊕⊕◯◯ Low
QoL (score)	4	RCT	seriouse	very seriousa	not serious	seriousb	none	174	182	0.02	SMD 2.94 higher (0.46 higher to 5.41 higher)	⊕◯◯◯ Very low

ADPN: Adiponectin, AE: Aerobic Exercise, BC: Breast Cancer, BF: Body Fat, BM: Body Weight, BMI: Body Mass Index, BMD: Bone Mineral Density, C: Control Group, CART: Combined Aerobic and Resistance Training, CI: confidence intervals, CRF: Cardiorespiratory Fitness, CRP: C-Reactive Protein, DBP: Diastolic Blood Pressure, DEP: Depression, EX: Exercise Group, FA: Cancer-related Fatigue, FFM: Fat-Free Mass, FG: Fasting Glucose, FI: Fasting Insulin, FM: Fat Mass, HC: hip circumference, HDL-C: High-Density Lipoprotein Cholesterol, HRmax: Maximum Heart Rate, HRR: Heart Rate Reserve, IL: Interleukin, LEP: Leptin, LDL: Low-Density Lipoprotein Cholesterol, MD: mean difference, NK: Natural Killer, RCT: randomized control trial, RT: Resistance Training, SBP: Systolic Blood Pressure, SMD: standardized mean difference, ST: standard treatment, SQ: Sleep Quality, TC: Total Cholesterol, TG: Triglycerides, TNF-α: Tumor Necrosis Factor α, QoL: Quality of Life, WC: Waist circumference, WHR: Waist-to-Hip Ratio, 1-RM: Repetition Maximum, a: there is considerable heterogeneity in the study's outcome, b: the included studies recorded a small sample size for both the control and intervention group, c: there is substantial heterogeneity in the studies, d: The assessor was not blinding, e: participants were aware of all exercise procedures, f: there is moderate heterogeneity in the involved studies.