Supplementary Table 1 List of the SNPs within the candidate genes which were analyzed for SF, their chromosomal loci, and their bone associated pathologies or other disorders.

Gene symbol	Gene	SNPs	SNPs analyzed / (total SNPs)	Chrom. loci	Bone pathology/other disorders
COL1A1 (MIM 120150)	Procollagen type I alpha 1	rs1061237, rs2277632, rs2586488, rs2075555, rs2075559	5 / (5)	17q21.3-q22.1	dOI, eOST, fEDS
COL1A2 (MIM 120160)	Procollagen type I alpha 2	rs420257, rs42518a, rs2521206, rs2621212, rs411717, rs6465412, rs369982, rs388625, rs11764718, rs42522, rs42531, rs2521205, rs1858822, rs42526, rs2621215, rs42517, rs413826	16 / (17)	7q22.1	dOI, eOST, fEDS
ESR1 (MIM 133430)	Estrogen receptor alpha	rs3020434, rs4583998a, rs9340799, rs3003924a, rs1643821, rs12199722, rs4870062, rs3778099, rs7755185, rs11155819, rs827420, rs2982712a, rs9322331, rs3020369, rs2077647, rs4870061, rs827421, rs3020404, rs9340933c, rs3020382, rs3020376a, rs6911230a, rs12662655c, rs3020370, rs3020394, rs6902771, rs3853248a, rs1709184, rs532010, rs3798577, rs9479130, rs1884052, rs2982896a, rs1709183, rs3020407, rs3844508a, rs4870056, rs1884051, rs2347867, rs9340835a, rs3020414c, rs2474148, rs1709182, rs3138774, rs2234693, rs9340954, rs1999805a	34 / (47)	6q25.1	eOST, gOSA
VDR (MIM 601769)	Vitamin D receptor	rs40734735, rs4334089, rs4237855a, rs1540339, rs2853564, rs3890734a, rs4760648, rs2239179, rs2248098, rs2525044, rs2239182, rs2107301, rs7136534, rs7299460, rs731236a, rs2254210, rs987849, rs4328262, rs11168287, rs7975232, rs10783219, rs38195845	19 / (22)	12q13.11	eOST
IGF1 (MIM 147440)	Insulin like growth factor	rs2195240, rs17796225, rs5009837, rs6214, rs7136446, rs5742629, rs10735380, rs4764697, rs11111272, rs9308315, rs12821878, rs2373721, rs10778176	13 / (13)	12q22-q23	eOST
IL6 (MIM 147620)	Interleukin 6	rs1554606, rs2069832, rs13306435c, rs11544633c, rs2069840, rs2069860b	3 / (6)	7q21	hBMD
TGF-β1 (MIM 190180)	Transforming growth factor, beta-1	rs8179181	1 / (1)	19q13.2	eOST
NR3C1 (MIM 138040)	Glucocorticoid receptor	rs12655166, rs4244032, rs852980c, rs9324911c, rs9324916, rs2963155c, rs6877893, rs258751c, rs2918417, rs7701443, rs852979, rs10482682, rs17100289, rs9324924, rs12656106, rs4607376, rs33388	13 / (17)	5q31.3	eOST, iOSP
CALCR (MIM 114131)	Calcitonin receptor	rs13226124, rs12154667, rs7783961, rs12666751c, rs2301680a, rs2214213, rs10237272, rs1548457, rs9656015, rs6465381, rs2299249, rs1548456, rs1801197, rs17788132, rs10282132b, rs10488551, rs2051748, rs12666831, rs2188805, rs757033, rs7790825, rs6970701b, rs2283002c, rs972978, rs2283004, rs9641123	21 / (26)	7q21.3	eOST
ANKH (MIM 605145)	Progressive ankylosis protein homolog	rs706293, rs17251763, rs258219, rs879253, rs1061813, rs31916, rs826188a, rs153930, rs1004673, rs258226, rs2453327, rs4701616, rs826352, rs10513186, rs1374080, rs2921600, rs875525, rs31912, rs1353258, rs31934, rs28005, rs379016, rs258231, rs1620976, rs10052744, rs40970, rs27353, rs31989a, rs17317655, rs3006069, rs1550826, rs697565, rs697571, rs744165, rs2454873, rs1697124, rs13170282c, rs4702049c, rs412056, rs258360a, rs398961, rs31911	37 / (42)	5p15.1	hBMD, jCL2, kCRD
TNFRSF11A (MIM 603499)	Activator of Nuclear Factor k B	rs1805034	1 / (1)	18q22.1	eOST
ROR2 (MIM 602337)	Receptor tyrosine kinase-like orphan receptor 2	rs10125466, rs7031729a, rs10992075, rs7869182, rs10761134, rs2312735a, rs4073735, rs10992149, rs7855522, rs6479385a, rs10761130a, rs7029814, rs9409461, rs10820921, rs10992145, rs7038397, rs11789973, rs7874148, rs4639579a, rs7037255, rs7039620, rs4467996, rs1534533, rs10992124, rs4744105a, rs4744107, rs7858435, rs10992123a, rs4744113, rs16907725, rs12683181, rs4743855, rs9774945, rs12685556c, rs9409652, rs10992072, rs10761129a, rs6479386, rs3905385, rs7021744, rs10992065, rs12376130, rs1881389a, rs4237215, rs7871522c, rs7863557, rs10992063, rs12554679, rs4595189, rs2141368, rs10992158	40 / (51)	9q22	lBTB, mRRS
CBG (MIM 122500)	Corticosteroid binding globulin	rs2281518, rs11160168, rs2144834, rs11629171, rs941599, rs11622970 a, rs1042394, rs2144835, rs2281519, rs1998056	9 / (10)	14q32.1	oCWP
LRP4 (MIM 604270)	Low density lipoprotein receptor-related protein 4	rs2306033	1 / (1)	11p11	eOST
LRP5 (MIM 603506)	Low density lipoprotein receptor-related protein 5	rs3736228, rs4988300a, rs4988321b	1 / (Jones, Bovee)	11q13.4	eOST, nOPS
BMP2 (MIM 112261)	Bone morphogenetic protein 2	s1980499, rs2273073, rs235764, rs15705	4 / (4)	20p12.3	eOST
ARHGEF3 (MIM 612115)	Rho guanine nucleotide exchange factor GEF 3	rs7646054, rs983739, rs1110866	3 / (3)	3p21-p13	eOST
Total SNPs	220 / (268)

Lower line- SNPs excluded from the statistical analysis, from the following reasons:- Not in HWE (Hardy-Weinberg Equilibrium)- MAF<10%- Not polymorphic Bone pathology and other disorders-OI- Osteogenesis imperfectaOST- Osteoporosis,EDS- Ehlers-Danlos syndromeOSA- OsteoarthritisBMD- Bone mineral densityOSP- OsteopeniaCL2- Chondrocalcinosis 2CRD- Craniometaphyseal DysplasiaBTB- Brachydactyly type BRRS- Recessive Robinow SyndromeOPS- Osteoporosis-Pseudoglioma syndromeCWP- widespread pain disorder.