Table 6. Analysis of the two-way and three-way interactions between ADRB2, ADRB3 and ADRA2A genes using quantitative multifactor dimensionality reduction for body composition parameters, lipids and glucose.
| Variables |
Best model* |
Cross-validation training score |
Cross-validation testing score |
CVC* |
p† |
| body mass (kg) |
Gly16Arg |
1.57 |
0.61 |
9/10 |
0.557 |
| BMI (kg/m2) |
Gly16Arg |
2.35 |
1.06 |
9/10 |
0.435 |
| %FM (%) |
Gly16Arg,G1780A |
2.45 |
-0.75 |
6/10 |
0.875 |
| FFM (kg) |
G1780A |
1.18 |
-2.29 |
6/10 |
0.995 |
| TBW (kg) |
Gly16Arg, Glu27Gln,Trp64Arg |
2.20 |
-1.86 |
6/10 |
0.986 |
| TC (mg/dL) |
Glu27Gln |
1.81 |
1.91 |
10/10 |
0.213 |
| TGL (mg/dL) |
Glu27Gln |
2.11 |
-1.56 |
6/10 |
0.969 |
| HDL (mg/dL) |
Trp64Arg, G1780A |
3.69 |
3.67 |
10/10 |
0.018 |
| LDL (mg/dL) |
Glu27Gln |
1.76 |
0.55 |
7/10 |
0.557 |
| Glucose (mg/dL) |
Gly16Arg,Glu27Gln, Trp64Arg |
2.45 |
-1.25 |
9/10 |
0.960 |
*ablethe best gene-gene interaction model was determined using cross-validation consistency (CVC) and cross-validation testing score† permuted p value (1000 permutations)
