The role of cognitive training in sports has experienced a recent surge in popularity. However, there is a paucity of longitudinal trials examining the effectiveness of related methods. This study aimed to investigate the impact of a cognitive training with minimal motor components on lower limb choice-reaction performance. A total of 44 healthy individuals (26.4 ± 3.7 years, 27 males) were randomly allocated to a cognitive training (CT) or an inactive control group (CON). The CT group participants, three times per week, engaged in a computerized exercise program targeting skills such as attention, reaction time, processing speed or inhibition control. Before and after the 6-week intervention period, lower limb choice-reaction time was assessed using the Quick Feet Board device. An ANCOVA of the post-intervention values, controlling for baseline data, demonstrated superior unilateral choice-reaction performance (stance on dominant leg) in the CT group (p = 0.04, r = 0.31). Conversely, no difference was found for the bilateral component of the test (p > .05). Off-court cognitive training may represent a suitable method to enhance reactive motor skills in athletes.