Table 1 Common Platelet-rich Therapy Preparation Systems. |
| System |
Volume
Of Blood
(mL) |
Centrifuge
Time/Speed |
Final PRP
Volume
(mL) |
Final Platelet
Concentration
(compared with
average) |
Activator |
Level of Growth
Factors (compared
with average) |
| Autologous Conditioned Plasma (Arthrex, Naples, FL)† |
9 |
5 min/1,500 rpm |
3-5 |
2-3x |
None |
PDGF (25x)
EGF (5x)
VEGF (11x)
TGF-β1 (4x)
IGF-1 (1x) |
Cascade (Musculoskeletal Tissue
Foundation, Edison, NJ)‡ |
9 or 18 |
First: 6 min/1,100g;
Second: 15 min/
1,450g |
2 or 4 |
N/A |
Calcium
(forms a
suturable
clot for
intraoperative
use) |
PDGF (N/A)
EGF (5-10x)
VEGF (5-10x)
TGF-β1 (5-10x)
IGF-1 (5-10x) |
| GPS III (Biomet, Warsaw, IN)§ |
27 or 54 |
15 min/1,900g |
3 or 6 |
4-8x |
Calcium
chloride/
thrombin |
PDGF (N/A)
EGF (3.9x)
VEGF (6.2x)
TGF-β1 (3.6x)
IGF-1 (1x) |
SmartPReP
(Harvest Technologies, Plymouth,
MA)†– |
20 or 60 |
14 min/1,000g |
3 or 7 |
4.4-7.6x |
Thrombin |
PDGF (4.4×)
EGF (4.4×)
VEGF (4.4×)
TGF-β1 (4.4×)
IGF-1 (N/A) |
|
* Information obtained from product manufacturers (platelet and growth factor concentration obtained from unpublished company data for all products listed except for Biomet GPS III [Eppley et al.]) |
† Arthrex: https://www.arthrex.com/innovations/index.cfm?adid=28&CFID=2168033&CFTOKEN=63754575 |
‡ Musculoskeletal Tissue Foundation: http://platelettherapy.com/ |
§ Biomet: http://www.biomet.com/biologics/information/pdf/BBI0003.0.pdf |
†– Harvest Technologies: http://www.harvesttech.com/products/smartprepmain.html |
EGF = epidermal growth factor, IGF-1 = insulin-like growth factor-1, N/A = not available, PDGF = platelet-derived growth factor |
PRP = platelet-rich plasma |
TGF-β1 = transforming growth factor-β1 |
VEGF = vascular endothelial growth factor |
|