Table 3. Macro and micro-vascular function by higher and lower aerobic fitness groups. Mean ± standard deviation. Peak oxygen uptake (mL·kg-0.61.min-1) Peak oxygen uptake (mL·FFM-1.min-1) Lower Higher Lower Higher Macrovascular PAI (%) 51.1±9.5 (n=46) 47.5±10.1 (n=47) 49.1±10.6 (n=41) 49.4±9.5 (n=52) Carotid to ankle PWV (m·s-1) 5.87±0.43 (n=45) 6.08±0.47* (n=45) 5.93±0.43 (n=40) 6.02±0.49 (n=50) Carotid to radial PWV (m·s-1) 6.62±0.72 (n=48) 6.66±0.78 (n=46) 6.58±0.63 (n=42) 6.68±0.83 (n=52) Microvascular FMR (V) 1.77±0.36 (n=48) 1.80±0.39 (n=48) 1.76±0.35 (n=43) 1.81±0.40 (n=53) Peak ACh response (V) 1.95±0.45 (n=48) 1.97±0.40 (n=45) 1.88±0.46 (n=40) 2.02±0.38 (n=53) ACh AUC (V x time) 478.3±141.3 (n=44) 480.8±124.5 (n=48) 458.4±130.5 (n=39) 495.2±132.3 (n=53) Peak SNP response (V) 1.64±0.49 (n=35) 1.57±0.50 (n=28) 1.54±0.46 (n=34) 1.69±0.53 (n=29) SNP AUC (V x time) 289.4±116.9 (n=35) 274.5±111.9 (n=28) 264.6±116.0 (n=34) 304.1±109.9 (n=29) Sample size (n=) is provided for each outcome. PAI - peripheral non-transformed augmentation index; PWV - pulse wave velocity. FMR - functional microvascular reserve; ACh - acetylcholine; AUC - area under the curve; SNP - sodium nitroprusside. Body mass index was entered as a covariate for carotid to ankle PWV. TBF% was added as a covariate for the SNP peak and AUC variables. * p < 0.05.