Supplementary Table 3. Threshold-gradient associations stratified by weekly MVPA volume.
Threshold MVPA volume (min/week) and pattern HR (95% CI) P value
Top two days ≥ 50% 150-250, regularly active 0.934 (0.828, 1.053) 0.264
150-250, weekend warrior 0.874 (0.819, 0.933) < 0.001
> 250, regularly active 0.880 (0.823, 0.941) < 0.001
> 250, weekend warrior 0.909 (0.857, 0.965) 0.002
Top two days ≥ 55% 150-250, regularly active 0.908 (0.831, 0.992) 0.033
150-250, weekend warrior 0.871 (0.810, 0.936) < 0.001
> 250, regularly active 0.884 (0.832, 0.938) < 0.001
> 250, weekend warrior 0.916 (0.857, 0.979) 0.010
Top two days ≥ 60% 150-250, regularly active 0.919 (0.849, 0.994) 0.036
150-250, weekend warrior 0.854 (0.790, 0.923) < 0.001
> 250, regularly active 0.897 (0.847, 0.949) < 0.001
> 250, weekend warrior 0.897 (0.832, 0.968) 0.005
Top two days ≥ 65% 150-250, regularly active 0.894 (0.833, 0.960) 0.002
150-250, weekend warrior 0.868 (0.793, 0.950) 0.002
> 250, regularly active 0.900 (0.853, 0.951) < 0.001
> 250, weekend warrior 0.883 (0.807, 0.966) 0.007
Top two days ≥ 70% 150-250, regularly active 0.887 (0.828, 0.949) < 0.001
150-250, weekend warrior 0.879 (0.794, 0.973) 0.013
> 250, regularly active 0.895 (0.848, 0.944) < 0.001
> 250, weekend warrior 0.913 (0.822, 1.014) 0.089
Top two days ≥ 75% 150-250, regularly active 0.882 (0.826, 0.941) < 0.001
150-250, weekend warrior 0.896 (0.796, 1.010) 0.072
> 250, regularly active 0.894 (0.848, 0.943) < 0.001
> 250, weekend warrior 0.927 (0.815, 1.053) 0.243
Top two days ≥ 80% 150-250, regularly active 0.889 (0.834, 0.947) < 0.001
150-250, weekend warrior 0.855 (0.740, 0.988) 0.033
> 250, regularly active 0.897 (0.851, 0.945) < 0.001
> 250, weekend warrior 0.905 (0.766, 1.069) 0.240
Top two days ≥ 85% 150-250, regularly active 0.894 (0.840, 0.952) < 0.001
150-250, weekend warrior 0.755 (0.614, 0.927) 0.007
> 250, regularly active 0.896 (0.851, 0.944) < 0.001
> 250, weekend warrior 0.925 (0.747, 1.146) 0.476
Top two days ≥ 90% 150-250, regularly active 0.896 (0.842, 0.953) < 0.001
150-250, weekend warrior 0.673 (0.522, 0.867) 0.002
> 250, regularly active 0.897 (0.852, 0.945) < 0.001
> 250, weekend warrior 0.889 (0.656, 1.206) 0.451
Top two days ≥ 95% 150-250, regularly active 0.887 (0.834, 0.943) < 0.001
150-250, weekend warrior 0.769 (0.527, 1.123) 0.174
> 250, regularly active 0.896 (0.851, 0.944) < 0.001
> 250, weekend warrior 1.049 (0.707, 1.555) 0.813
HRs were estimated using Cox proportional hazards models stratified by weekly MVPA volume. The exposure was the physical activity pattern defined separately at each top-two-day threshold: inactive (<150 min/week of MVPA), WW (>=150 min/week and at least the stated percentage of total weekly MVPA on the two most active days), or regularly active (>=150 min/week and below the stated percentage). Active WW and regularly active participants were further classified as 150-250 or >250 min/week of MVPA; inactive participants were the reference group for every comparison. The outcome was incident overall OA, defined as the first recorded ICD-10 M15-M19 diagnosis during follow-up among participants without OA at baseline. Models adjusted for age at accelerometer assessment, sex, ethnicity, education, Townsend deprivation index, smoking status, alcohol intake frequency, and BMI. Abbreviations: BMI, body mass index; CI, confidence interval; HR, hazard ratio; ICD-10, International Classification of Diseases, 10th Revision; MVPA, moderate-to-vigorous physical activity; OA, osteoarthritis; WW, weekend warrior.