Exercise is commonly used as an intervention to increase caloric output and positively affect body composition. A major challenge is the low compliance often seen when the prescribed exercise is associated with high levels of exertion. Whole-body vibration (WBV) may allow increased caloric output with reduced effort; however, there is limited information concerning the effect of WBV on oxygen consumption (VO₂). Therefore, this study assessed the synergistic effects of resistance training and WBV on VO₂. We examined VO₂ at different loads (0%, 20%, and 40% body weight (BW)) and vibration intensities (No vibration (NV), 35HZ, 2-3mm (35L), 50Hz, 57mm (50H)) in ten men (26.5 ± 5.1 years). Data were collected during different stages (rest, six 30s sets of squatting, and recovery). Repeated measures ANOVA showed a stage x load x vibration interaction. Post hoc analysis revealed no differences during rest; however, a significant vibration x load interaction occurred during exercise. Both 35L and 50H produced greater VO₂ than NV at a moderate load of 20%BW. Although 40%BW produced greater VO₂ than 20%BW or 0%BW using NV, no significant difference in VO₂ was seen among vibratory conditions at 40%BW. Moreover, no significant differences were seen between 50H and 35L at 20%BW and NV at 40%BW. During recovery there was a main effect for load. Post hoc analyses revealed that VO₂ at 40%BW was significantly higher than 20%BW or 0%BW, and 20%BW produced higher VO₂ than no load. Minute-by-minute analysis revealed a significant impact on VO₂ due to load but not to vibratory condition. We conclude that the synergistic effect of WBV and active squatting with a moderate load is as effective at increasing VO₂ as doubling the external load during squatting without WBV.